Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection.

نویسندگان

  • Cormac Cosgrove
  • James E Ussher
  • Andri Rauch
  • Kathleen Gärtner
  • Ayako Kurioka
  • Michael H Hühn
  • Krista Adelmann
  • Yu-Hoi Kang
  • Joannah R Fergusson
  • Peter Simmonds
  • Philip Goulder
  • Ted H Hansen
  • Julie Fox
  • Huldrych F Günthard
  • Nina Khanna
  • Fiona Powrie
  • Alan Steel
  • Brian Gazzard
  • Rodney E Phillips
  • John Frater
  • Holm Uhlig
  • Paul Klenerman
چکیده

HIV infection is associated with immune dysfunction, perturbation of immune-cell subsets and opportunistic infections. CD161++ CD8+ T cells are a tissue-infiltrating population that produce IL17A, IL22, IFN, and TNFα, cytokines important in mucosal immunity. In adults they dominantly express the semi-invariant TCR Vα7.2, the canonical feature of mucosal associated invariant T (MAIT) cells and have been recently implicated in host defense against pathogens. We analyzed the frequency and function of CD161++ /MAIT cells in peripheral blood and tissue from patients with early stage or chronic-stage HIV infection. We show that the CD161++ /MAIT cell population is significantly decreased in early HIV infection and fails to recover despite otherwise successful treatment. We provide evidence that CD161++ /MAIT cells are not preferentially infected but may be depleted through diverse mechanisms including accumulation in tissues and activation-induced cell death. This loss may impact mucosal defense and could be important in susceptibility to specific opportunistic infections in HIV.

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عنوان ژورنال:
  • Blood

دوره 121 6  شماره 

صفحات  -

تاریخ انتشار 2013